| QTL Map Information |
|---|
| Chromosome: | 22 |
| QTL Peak Location: | 71.05 (cM) |
| QTL Span: | 57.7-82.9 (cM)
35.9-51.5 (Mbp) |
 |
Upper, "Suggestive": | n/a |
| Upper, "Significant": | BM6041 |
| Peak: | |
| Lower, "Significant": | MCM373 |
| Lower, "Suggestive": | n/a |
| Marker type: | Microsatellites |
| Analysis type: | Association |
| Model tested: | Mendelian |
| Test base: | n/a |
| Threshold significance level: | Significant |
 |
P_values | 0.022 | | Dominance effect: | n/a |
| Additive effect: | n/a |
| Associated Gene: | SPRN (shadow of prion protein homolog (zebrafish)) |
| Cis/Trans acting type: |  |
| Links:
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| Extended information: |
|---|
| (none) |
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| QTL Experiment in Brief |
|---|
| Animals: | Animals were from 25 different breeds of sheep. |
| Breeds associated:
n/a
|
| Design: | Animals were genotyped for 26 mutations in SPRN and analyzed for scrapie susceptibility. |
| Analysis: | A Cochran-Mantel-Haenszel test comparing the three genotypes and using the PRNP genotype as stratification factor was used. |
| Software: | SAS |
| Notes: | |
| Links: | Edit |
| Reference |
|---|
| Authors: | Lampo E, Duchateau L, Schepens B, Van Poucke M, Saelens X, Erkens T, Van Zeveren A, Peelman LJ |
| Affiliation: | Department of Nutrition, Genetics and Ethology, Ghent University, Merelbeke, Belgium |
| Title: | Identification of polymorphisms in the ovine Shadow of prion protein (SPRN) gene and assessment of their effect on promoter activity and susceptibility for classical scrapie |
| Journal: | Animal Genetics, 2010, 41(2): 169-78 |
| Links: |
PubMed | Abstract | List all data
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| Additional Information |
|---|
| Comments: | g.2263_2268del |
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