PPT Slide
Regression Interval Mapping
to map QTL in half-sib family designs
Need to allow for different marker-QTL linkage phase by family
Model for phenotype of progeny j of sire i
Yij = mi + bQ,i XQ,ij + eij Allow for different linkage phase by family
XQ,ij = Prob(Qi | marker genotype, QTL position)
= prob. Progeny received paternal QTL allele that is
that is in coupling with, e.g. MN haplotype in the sire
E(bQ,i) = ai = QTL substitution effect for sire i